Please use this identifier to cite or link to this item:
Title: Colon Motility in The Rats After Long-Term Treatment of Omeprazole and Pantoprazole
Authors: Корінчак, Любов Миколаївна
Koval, A. A.
Beregova, T. V.
Pylypenko, S. V.
Keywords: proton pump inhibitors
Issue Date: 2018
Publisher: Іnternational online journal
Citation: Colon Motility in The Rats After Long-Term Treatment of Omeprazole and Pantoprazole [Електронний ресурс] / S. V. Pylypenko, A. A. Koval, L. M. Korinchak, T. V. Beregova // RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES. – 2018. – Режим доступу до ресурсу:[237].pdf
Abstract: The aim of the study was to investigate the consequences of long-term use of proton pump inhibitors (PPIs) on colon motility in the rats. The study was done on 30 male albino rats which were divided into 3 groups. As a control were rats, which were injected 0.2 ml of water for 28 days intraperitoneally (i.p.). The rats of second group received omeprazole (“Sigma Aldrich”, USA) and the rats of third group – pantoprazole (Ulsepan, “World Medicine”, Great Britain) in dose 14 mg/kg i.p. once a day for 28 days. One day after the last administration of drugs, the spontaneous and stimulated by carbachol colon motility was recorded by the balloongraphic method. Gastrin concentration in blood serum was determined by the radioimmune method. Long-term use of omeprazole and pantoprazole leads to diminishing of spontaneous and stimulated by carbachol colon motility and increase of gastrin concentration in blood serum by 3,1-fold and 1,6-fold consequently. We concluded that suppression of colon motility after long-term use of PPIs is the result of hypergastrinemia evoked by diminishing of gastric acid secretion. The effect of omeprazole on colon motility was expressed more strongly which we associate with its greater effect on the growth of gastrin concentration
ISSN: 0975-8585
Appears in Collections:Факультет фізичного виховання

Files in This Item:
File Description SizeFormat 
1.pdf356,73 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.