Please use this identifier to cite or link to this item: https://dspace.udpu.edu.ua/handle/123456789/15787
Title: Prebiotic prevents the development of gastrointestinal motility disorders caused by omeprazole
Other Titles: Пребіотик запобігає розвитку порушень моторики шлунково-кишкового тракту, спричинених омепразолом
Authors: Корінчак, Любов Миколаївна
Keywords: stomach
colon
spontaneous and stimulated contractions
carbachol
omeprazole
lactulose
Issue Date: 2023
Publisher: Київ: Fiziologichnyi Zhurnal
Citation: Korinchak L.M. Prebiotic prevents the development of gastrointestinal motility disorders caused by omeprazole. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine. Fiziol. Zh. 2023; 69(5): 83-88.
Series/Report no.: УДК;612.3+616.3+616-008.64
Abstract: The synthetic disaccharide lactulose, consisting of fructose and galactose, after oral administration in an unchanged form reaches the lower part of the gastrointestinal tract, where under the action of normal flora it is broken down into short-chain fatty acids that stimulate colon motility. The effect of lactulose on gastrointestinal tract motility in the conditions of its long-term suppression by omeprazole has not been investigated. We studied the influence of lactulose on spontaneous and carbachol-stimulated gastric and colonic motility in rats treated with omeprazole for 28 days. The animals were divided into 3 groups. The first group of animals served as a control. The animals in the second group were administered omeprazole intraperitoneally at a dose of 14 mg/kg orally once a day for 28 days. The animals in the third group were simultaneously injected intraperitoneally with omeprazole and prebiotic lactulose at a dose of 0.2 g/kg orally once a day for 28 days. On the day after the last injections of drugs, we investigated the spontaneous and carbachol-stimulated contractions in the stomach and colon by the balloon graphic method. It was found that the frequency of spontaneous and stimulated contractions in the stomach and colon did not change significantly after 28 days of omeprazole treatment. The amplitude and index of spontaneous and carbachol-stimulated contractions in the stomach and colon were significantly weaker compared to the control. One day after the 28-day simultaneous administration of omeprazole and lactulose the amplitude and index of spontaneous and stimulated contractions in the stomach and colon increased compared with the group of rats treated with omeprazole alone. We concluded that the positive effect of lactulose on gastric and colon motility is a result of the prebiotic properties of lactulose which leads to the normalization of the microbiocenosis in the gastrointestinal tract and the elimination of the inflammatory process in it.
Description: https://fz.kiev.ua/index.php?abs=2007
URI: https://dspace.udpu.edu.ua/handle/123456789/15787
ISSN: 2522-9028
Appears in Collections:Факультет фізичного виховання

Files in This Item:
File SizeFormat 
Корінчак.pdf319,96 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.